6/12/2023 0 Comments Termaks manualPathogenetically OA exhibits changes in osteochondral tissue, i.e. Osteoarthritis (OA) is one of the leading causes of disability worldwide. The method is a candidate for a future approach for managing OA. To conclude, HIFU delivers molecules into articular cartilage without major short-term concerns about safety. Adjacent control 1 tissue ( n = 10) was first pre-treated with HIFU followed by immersion into MB adjacent control 2 tissue ( n = 10) was immersed in MB without ultrasound exposure. HIFU-treated samples ( n = 10) were immersed in a methylene blue (MB) solution during sonication ( f = 2.16 MHz, peak-positive-pressure = 3.5 MPa, mechanical index = 1.8, pulse repetition frequency = 3.0 kHz, cycles per burst: 50, duty cycle: 7%). In this study, we aimed to deliver methylene blue locally into bovine articular cartilage in vitro. High-intensity focused ultrasound (HIFU) provides a means to actuate matter from a distance in a non-destructive way. Localized delivery of drugs into an osteoarthritic cartilaginous lesion does not yet exist, which limits pharmaceutical management of osteoarthritis (OA).
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